A number of confocal scanning laser ophthalmoscopy, scanning laser polarimetry, and optical coherence tomography oct devices have been cleared by the u. Methods participants of the populationbased northern finland birth cohort eye study, aged 45 to 49 years. In addition to standard automated perimetry, gonioscopy, fundus photography, and stereophotography, other advanced, highresolution methods for imaging the eye in glaucoma are explained in detail. Although these techniques differ, the objective is the. As it goes through tubules, it returns at a different orientation axis. Birefringence and depolarization were observed in the area with deep retinal lesions in macular disease. Recently, scanning laser polarimetry was used to selectively emphasize the different layers of the retina. Scanning laser polarimetry of a patient with degenerative myopia demonstrating irregular high spikes in the tsnit temporal, superior, nasal, inferior, temporal graph and an overall increase in retinal nerve fibre layer thickness in all peripapillary quadrants in the colour thickness map. Scanning laser polarimetry slp has been proposed as a useful diagnostic test for glaucoma. Scanning laser polarimetry in normal subjects and patients. Pdf the quality of reporting of diagnostic accuracy.
Analytical methods for scanning laser polarimetry osa. Scanning laser polarimetry is a technique for assessing the thickness of the retinal nerve fiber layer in vivo. Diagnostic performance of modern imaging instruments in. Analytical model of scanning laser polarimetry for retinal nerve. Assessment of nerve fiber layer in diabetic patients with scanning laser polarimetry.
For example, the rtvue xr oct avanti optovue is an oct system. Scanning laser polarimetry slp is based on the birefringence properties of ganglion cell axon neurotubules that alter the laser scanning beam polarization acco rding to the rnfl thickness. Correlation between local glaucomatous visual field defects and loss of nerve fiber layer thickness measured with scanning laser polarimetry and spectral domain optical coherence tomography. The effects of poor anterior segment compensation on scanning laser polarimetry measurements of. Effects of inadequate anterior segment compensation on. Scanning laser polarimetry images were obtained using a commercial gdx vcc system version 5. This so called retardation is thought to be linearly correlated with nerve fiber layer thickness. Dreher and klaus reiter scanning laser polarimetry of the retinal nerve fiber layer, proc.
Zeiss gdx pro 8000 is the only commercially available, currentgeneration scanning laser polarimeter. The first commercial scanning laser polarimeter was the the nerve fiber layer and scanning laser polarimetry the history and utility of this technology. Ophthalmic surgery, lasers and imaging retina abstract. Pdf to compare the abilities of scanning laser polarimetry with the variable corneal compensator gdx vcc with. Scanning laser polarimetry, retinal birefringence, light retardation, retinal nerve fiber layer, glaucoma, anterior segment birefringence. Scanning laser polarimetry reveals status of rnfl integrity in eyes with optic nerve head swelling by oct mark j. Scanning laser polarimetry versus matrix perimetry, optical coherence tomography, and retinal nerve fiber layer photography using heidelberg retina angiograph 1.
A basic understanding of how birefringence and retardation is vital to understand how this tech pictures the optic nerve. Factors affecting image acquisition during scanning laser. In addition to standard automated perimetry, gonioscopy, fundus photography, and stereophotography, other advanced, highresolution methods for imaging the eye in glaucoma are explained in detail, including ultrasound biomicroscopy, confocal scanning laser ophthalmoscopy, scanning laser polarimetry, and spectral domain optical coherence tomography. Scanning laser polarimetry laser light enters eye at specific orientation. Technology today the nerve fiber layer and scanning. Optical coherence tomography and scanning laser polarimetry slp are the techniques that utilize the. Objective to determine if scanning laser polarimetry slp measures form birefringence of the retinal nerve fiber layer rnfl methods consecutive patients with either acute unilateral disc edema or chronic diffuse unilateral disc atrophy underwent slp using the gdx nerve fiber analyzer laser diagnostic technologies inc, san diego, calif. To confirm the origin of these polarization changes, layer by layer analysis is required. Food and drug administration fda through the 510k process for imaging the posterior eye segment.
Ophthalmologic techniques that evaluate the posterior. The model is based on image series of 23 healthy eyes and incorporates colored noise, incomplete cornea compensation and masking by the retinal blood vessels. Three separate scans were obtained, and a baseline scan was created and used in the analyses. This article will discuss information on evaluation of the intrabulbar structure of the optic nerve as it relates to glaucoma, with particular emphasis on three imaging devices, confocal scanning laser ophthalmoscopy, optical coherence tomography, and scanning laser polarimetry. Optical coherence tomography oct shows retinal nerve.
Imaging polarimetry in macular disease with scanning laser. Pdf comparison between gdx vcc scanning laser polarimetry. Spectraldomain optical coherence tomography and scanning. Optical coherence tomography applies the principle of interferometry to determine the interface between different ocular tissues. Confocal scanning laser ophthalmoscopy, glaucoma, oct, retinal nerve fiber layer, scanning laser polarimetry. Purposeto compare sensitivity and specificity of retinal nerve fiber layer thickness rnflt measurements made using rtvue100 fourierdomain optical coherence tomography rtvueoct and scanning. Detection of glaucoma using scanning laser polarimetry with.
Scanning laser polarimetry of edematous and atrophic optic. Scanning laser polarimetry in glaucoma t anuj dada, reetika sharma, dewang angmo, gautam sinha, shibal bhartiy a, sanjay k mishra, anita panda, ramanjit sihota. The retardation value is proportionate to the thickness of the rnfl fig. Scanning laser polarimetry an overview sciencedirect. Scanning laser polarimetry of the retinal nerve fiber layer.
In the retina, the parallel arrangement of the microtubules. Optical coherence tomography, scanning laser polarimetry. Retinal ganglion cells and their axons represent the. Scanning laser polarimetry in monkey eyes using variable corneal polarization compensation. Background optical coherence tomography oct and scanning laser polarimetry with variable corneal compensation gdx are similar yet provide information on different aspects of retinal nerve fiber layer rnfl structure thickness values similar to histology for oct vs birefringence of. Optical coherence tomography, scanning laser polarimetry and confocal scanning laser ophthalmoscopy in retinal nerve fiber layer measurements of glaucoma patients farsad fanihagh 1, stephan kremmer, 1, 2, gerasimos anastassiou 1, 2, maurice schallenberg 2, 3, klauspeter steuhl 2, michael selbach 1, 2. I read with interest the article titled factors affecting image acquisition during scanning laser polarimetry by tien hoh et al.
Optic nerve and retinal nerve fiber imaging eyewiki. Aims to examine the changes in the retinal nerve fibre layer nfl thickness with age and myopia in normal population methods retinal nerve fibre layer thickness was measured with a scanning laser polarimeter nfai in 180 normal subjects of varying age range 783 years and in 110 eyes of 85 patients with myopia of varying degrees range. Scanning laser polarimetry slp has undergone multiple hardware and software changes, particularly in neutralizing anterior segment birefringence, to improve its ability to recognize retinal nerve fiber layer retardation. Aim to evaluate the applicability of imaging devices spectraldomain optical coherence tomography cirrus sdoct, scanning laser polarimetry gdx and scanning laser ophthalmoscopy heidelberg retinal tomograph, hrt3 for glaucoma screening in a middleaged unselected population. Pdf optical coherence tomography, scanning laser polarimetry. Retinal degeneration in progressive supranuclear palsy measured by optical coherence tomography and scanning laser polarimetry. To develop a quantitative understanding of scanning laser polarimetry slp for. Gdxpro, the worlds only scanning laser polarimeter, provides a unique measurement derived from both rnfl thickness and rnfl structural organization. These results are often considered along with other findings to make diagnostic and therapeutic decisions.
Pdf scanning laser polarimetry in eyes with exfoliation. Gdxpro scaning laser polarimetry glaucoma carl zeiss. Clinical studies in scanning laser polarimetry core. Technology today the nerve fiber layer and scanning laser. Each of these diagnostic tools is based on different imaging modalities. These techniques are optical coherence tomography oct, scanning laser polarimetry slp and confocal scanning laser ophthalmosopy cslo. Near infrared wavelength laser double passes the retinal nerve fiber layer nfl and is split into 2 parallel rays by the birefringent fibers. Though the technology has been available for several years, recent advances have resulted in improved imaging capabilities that may enhance clinicians ability to identify and follow the progression of glaucoma. Scanning laser polarimetry measures change in the linear polarization of light retardation. However a dutch study found that while there is a correlation between standard automated perimetry and gdx vcc measurements in patients with glaucoma, suggesting that gdx. Comparison of scanning laser polarimetry using variable corneal compensationand retinal nerve fiber layer photography for detection of glaucoma. In all subjects, both eyes were scanned with the gdx vcc, starting with the right eye. Pdf effect of peripapillary chorioretinal atrophy on gdx.
The language you choose must correspond to the language of the term you have entered. Original contribution retinal imaging by laser polarimetry and optical coherence tomography evidence of axonal degeneration in multiple sclerosis. Hence, the measurement of rnfl thickness has come up. Detection of glaucoma with scanning laser polarimetry. To evaluate and compare the diagnostic accuracies for glaucoma detection of scanning laser polarimetry slp with enhanced corneal compensation gdx. Gdxpro scaning laser polarimetry glaucoma carl zeiss meditec international.
Longterm followup of scanning laser polarimetry and confocal scanning laser ophthalmoscopy in normal tension glaucoma kremmer s 1,2, darwesh s 2, anastassiou g 1,2, steuhl kp and selbach jm1,2 1eye hospital, evangelisches krankenhaus gelsenkirchen, munckelstr. Pdf comparison of scanning laser polarimetry using. The main birefringent intraocular tissues are the cornea, lens and the retina. Scanning computerized ophthalmic diagnostic imaging devices.
Scanning laser polarimetry in eyes with exfoliation syndrome. Kupersmith,1 randy kardon,2 mary durbin,3 melissa horne,3 and julia shulman4 purpose. Scanning laser polarimetry is performed by a confocal scanning laser ophthalmoscope with an integrated polarimeter gdxvcc. To determine the correlations and strength of association between different imaging systems in analyzing the retinal nerve fiber layer rnfl of glaucoma patients. Gdxpro uses a nearinfrared laser 780nm in a raster pattern to image the macula and peripapillary region. It uses both a polarimeter an optical device to measure linear polarization change and a scanning laser ophthalmoscope, to measure the thickness of the nerve fiber layer of the retina. Scanning laser polarimetry is an imaging technology that is utilized to measure peripapillary rnfl thickness. Relationship between visual field sensitivity and retinal.
The commercially available scanning laser ophthalmoscope is made by heidelberg engineering, and is called. Retinal imaging by laser polarimetry and optical coherence. Pdf scanning laser polarimetry in monkey eyes using. Imaging polarimetry in macular disease with scanning laser polarimetry and. Scanning laser polarimetry came onto the market in 1993.
Voci con modulo citazione e parametro pagine voci con modulo citazione e parametro coautori stub. Scanning laser polarimetry an overview sciencedirect topics. One eye from 84 healthy individuals and 83 patients with early to moderate glaucomatous visual field loss 167 eyes was assessed with a scanning laser polarimeter laser diagnostic technologies, san diego, calif. The working principle is based on the fact that in the nerve fiber layer a phase shift occurs in polarized laser light that is sent through the nerve fiber layer. The optical coherence tomography oct, confocal scanning laser ophthalmoscopy cslo, and scanning laser polarimetry slp are three prevailing glaucoma imaging technologies that have evolved rapidly over the recent years in both hardware and software configurations. Scanning laser polarimetry slp, a technology for glaucoma diagnosis, uses. Assessment of nerve fiber layer in diabetic patients with. Pdf retinal degeneration in progressive supranuclear. Optical coherence tomography, scanning laser polarimetry and. This study was conducted to evaluate the quality of reporting of published studies using the slp for diagnosing glaucoma.
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